Ousmane Dembele, Frenkie de Jong, Samuel Umtiti and Junior Firpo are sidelined due to injury.
Griezmann will likely get another start after an impressive showing in the win at Villarreal.
Barcelona matchday squad: ter Stegen, N. Semedo, Piqué, I. Rakitic, Sergio, Arthur, Suárez, Messi, Neto, Lenglet, Griezmann, Jordi Alba, Braithwaite, S. Roberto, Vidal, Iñaki Peña, Riqui Puig, Collado, Ansu Fati, R. Araujo, Morer, Monchu i J. Cuenca.
Head to head (h2h) history and results
Espanyol held Barca to a 2-2 draw in the reverse fixture back in January, though Barca dominate this fixture historically with 123 wins to Espanyol's 44 in 211 derbies.
Barcelona possible starting lineup:
Ter Stegen; Semedo, Pique, Lenglet, Alba; Roberto, Busquets, Vidal; Messi; Suarez, Griezmann
Espanyol possible starting lineup:
Diego Lopez; J. Lopez, Espinosa, Cabrera, Vila; Roca, David Lopez; Melendo, Darder, Embarba, Tomas